I was always partial to the Brittania II from the Lensman anime-
I'd love to see someone go back to the original
Lensman books that
Lensman was very (!!!) loosely adapted from and do those ships. I especially want to see the original
Brittania as well as Kimball Kinnison's "Speedster".
Mind you, if the reported live action version of the first main book in the series,
Galactic Patrol gets made, we may see some interesting interpretations. Supposedly JMS is doing the writing on it - which is appropriate because he's a strong fan of the novels.