Hmm, combine the Griffon-engined with superchargers version with leading edge radiators and intercoolers and the extended "Lightning Swordfish" center nacelle and you'd have an advanced version of what I've read Kelly Johnson considered to be the ultimate P-38.
As an alternate thought, take one of the radial-engined derivatives proposed to the US Navy and replace the original engines with R2800s or R3350s.